Damage is estimated at $450,000 after a garage fire in London sent two people to hospital and caused extensive damage to a home Wednesday morning. Fire crews were called to Avenue Road just before 9:30 a.m. following reports of a fire involving an attached garage. Upon arrival, firefighters launched an initial offensive attack and were able to quickly knock down the blaze. Crews later switched to a defensive strategy after part of the roof structure collapsed. Officials said the fire caused extensive damage to both the attached garage and the home. Two people were transported to Victoria Hospital. The extent of their injuries has not been released. No information on the cause of the fire was immediately available. The incident remains under investigation.